Isoniazid

Effect of secondary preventive therapy on recurrence of tuberculosis in HIV-infected individuals: a systematic review

Human immunodeficiency virus (HIV)-infected individuals successfully treated for tuberculosis (TB) remain at risk of recurrence of the disease, especially in high TB incidence settings. We performed a systematic review, investigating whether …

Evaluation of the Genotype® MTBDRplus assay as a tool for drug resistance surveys

SETTING A national tuberculosis (TB) drug resistance survey in Tanzania. OBJECTIVE To compare the performance of the Genotype® MTBDRplus line-probe assay (LPA) on smear-positive sputum specimens with conventional culture and isoniazid (INH) plus …

Patient-centred tuberculosis treatment delivery under programmatic conditions in Tanzania: a cohort study

BACKGROUND: Directly observed therapy (DOT) remains the cornerstone of the global tuberculosis (TB) control strategy. Tanzania, one of the 22 high-burden countries regarding TB, changed the first-line treatment regimen to contain …