Drug Resistance

Use and impact of molecular methods for detecting drug-resistant TB.

Rapid assessment of antimicrobial resistance prevalence using a Lot Quality Assurance sampling approach

AIM: Increasing antimicrobial resistance (AMR) requires rapid surveillance tools, such as Lot Quality Assurance Sampling (LQAS). MATERIALS & METHODS: LQAS classifies AMR as high or low based on set parameters. We compared classifications with the …

Epidemiological surveys embedded in technical assistance to Tuberculosis control Programmes

Many National Tuberculosis Programmes (NTPs) receive Technical Assistance (TA) for the implementation and evaluation of their TB-control strategies. KNCV tuberculosis Foundation (KNCV) in the Netherlands is a TA organization providing assistance for …

Multidrug resistance among new tuberculosis cases: detecting local variation through lot quality-assurance sampling

BACKGROUND: Current methodology for multidrug-resistant tuberculosis (MDR TB) surveys endorsed by the World Health Organization provides estimates of MDR TB prevalence among new cases at the national level. On the aggregate, local variation in the …

Evaluation of the Genotype® MTBDRplus assay as a tool for drug resistance surveys

SETTING A national tuberculosis (TB) drug resistance survey in Tanzania. OBJECTIVE To compare the performance of the Genotype® MTBDRplus line-probe assay (LPA) on smear-positive sputum specimens with conventional culture and isoniazid (INH) plus …

National anti-tuberculosis drug resistance study in Tanzania

OBJECTIVE: To assess the prevalence of anti-tuberculosis drug resistance in a national representative sample of tuberculosis (TB) patients in Tanzania according to recommended methodology. DESIGN: Cluster survey, with 40 clusters sampled proportional …

National anti-tuberculosis drug resistance study in Tanzania

OBJECTIVE: To assess the prevalence of anti-tuberculosis drug resistance in a national representative sample of tuberculosis (TB) patients in Tanzania according to recommended methodology. DESIGN: Cluster survey, with 40 clusters sampled proportional …

Implementation of a national anti-tuberculosis drug resistance survey in Tanzania

ABSTRACT: BACKGROUND: A drug resistance survey is an essential public health management tool for evaluating and improving the performance of National Tuberculosis control programmes. The current manuscript describes the implementation of the first …

Determination of Clinically Relevant Cutoffs for HIV-1 Phenotypic Resistance Estimates Through a Combined Analysis of Clinical Trial and Cohort Data

BACKGROUND:: Clinically relevant cutoffs are needed for the interpretation of HIV-1 phenotypic resistance estimates as predicted by ''virtual'' phenotype HIV resistance analysis. METHODS:: Using a clinical data set containing 2596 treatment change …

[The use of the non-nucleoside reverse transcriptase inhibitors nevirapine and efavirenz in the treatment of patients with a chronic HIV-I infection]

The non-nucleoside reverse transcriptase inhibitors (NNRTIs) are an important group ofantiretroviral drugs in the treatment of a chronic HIV-I infection. The risk of viral resistance to NNRTIs is strongly diminished when they are used as part of a …