Lot Quality Assurance Sampling


The central objective of this project is to validate, optimize and implement the use of lot quality assurance sampling (LQAS) as a tool for surveillance of antimicrobial resistance (AMR), and a feasible strategy to timely inform local antimicrobial stewardship activities.

PART 1: Simulating LQAS-based AMR surveillance using existing data on drug-resistant tuberculosis, and on drug resistance in urinary tract infections (UTI).

PART 2: Validating the strategy against a conventional drug resistance survey in outpatients and inpatients suspected of UTI in 11 sites from 2 islands of Indonesia (Java [Bandung], and Sumatra [Medan]).

PART 3: Implementing LQAS-based surveilance within a One-Health framework. Within the human domain, the project moves from a static to a dynamic version of LQAS-based AMR surveillance in outpatients suspected of UTI in Burkina Faso and Togo. Within the veterinary domain, the project introduces a static LQAS-based AMR surveillance at the level of farms under the respsonsibility of a single veterinary in Germany. AMR will be assessed from aggregated faeces collected from trucks that deliver animals to slaughter houses.

Funding: PART 1 and PART 2: Netherlands Academy of Science (KNAW); PART 3: JPIAMR

Project partners: PART 1 and PART 2: Universitas Padjadjaran, Bandung, Indonesia; University of Sumatera Utara, Medan, Indonesia; Amsterdam University Medical Centers, location AMC; PART 3: Fondation Merieux, France; Friedrich-Loeffler Institute, Germany; Institute of Hygiene and Infectious Diseases of Animals, Germany; University Hospital of Lomé, Togo; Nazi Boni University, Burkina Faso.

Timing: PART 1 and PART 2: 2013 - 2020; PART 3: 2020 -

Frank van Leth
Associate Professor